In a Purchase & Sale Agreement, there are essential clauses that protect both the buyer and the seller. These clauses are important as they outline the rights and responsibilities of each party involved in the transaction. Some of the key clauses to look out for include the inspection contingency, which allows the buyer to have the property inspected before finalizing the purchase, the financing contingency, which gives the buyer a way out of the agreement if they can't secure a loan, and the earnest money clause, which specifies the amount of money the buyer must deposit as a sign of good faith. For the seller, essential clauses include the disclosure clause, which requires the seller to disclose any known issues with the property, and the closing date, which sets a deadline for the completion of the sale. Understanding these clauses is crucial for a smooth and fair real estate transaction.